University of California, Riverside

Department of Electrical and Computer Engineering

In vivo optical molecular imaging of the VEGF for monitoring cancer treatment

In vivo optical molecular imaging of the VEGF for monitoring cancer treatment
Sung K. Chang
Massachusetts General Hospital

Date: Friday March 23, 2007
Time: 11:00am
Location: A265 Bourns Hall

Dysregulation of cell-to-cell signaling by cytokines is characterized in various diseases including cancer.  As a result, monitoring cytokine expression can provide insights into the disease progression and appropriate intervention strategies.  Current ex vivo biochemical assays for quantifying cytokine concentration are limited in sensitivity or are highly invasive.  Recent advances in optical imaging technology can provide the capabilities to probe the spatio-temporal dynamics of such molecular processes in vivo and in real-time.  In this talk, I will present the development of an in vivo optical molecular imaging strategy for monitoring one of the cytokines, the vascular endothelial growth factor (VEGF) that is a critical component in tumor growth and metastasis.  With the imaging strategy, changes in tumoral VEGF concentration following subcurative photodynamic therapy (PDT) and Avastin anti-VEGF therapy were monitored in vivo.  Capabilities to monitor dynamic changes in cytokine expression in vivo and in real-time can potentially help develop effective tools for diagnosis, prognosis, treatment planning and monitoring in the future.

About the speaker:

Dr. Sung Chang graduated from the Department of Electronic Engineering at Yonsei University in Seoul, Korea in 1997. After his graduation, he worked at Samsung Electronics to design digital signal processing modules for telecommunication systems. He then joined the graduate program at the Electrical and Computer Engineering Department at the University of Texas at Austin. His doctoral research focused on the development of an optics-based non-invasive, in vivo diagnostic tool for detecting cervical pre-cancer. Since 2004, he joined the Wellman Center for Photomedicine at the Massachusetts General Hospital in Boston as a postdoctoral research fellow, where he is developing optical imaging strategies to monitor response to cancer treatment.
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